Extreme Stress

What would make a man age 20yrs in a matter of five years. A before and after pic of Abraham Lincoln. His first ever portrait and his last. May 1860 vs Feb 1865.  1860 and 1865 are the beginning and end years of the American Civil War. The enormous stress of being President and the excruciatingly difficult decisions he had to make during the war. The illness and death of a young son. The frail mental health of his wife. Any one of those factors would be considered extreme stress. Rest in peace Mr Lincoln. Job well done.